A while ago I read The Art of Approaching Women. Since then I just make eye contact with the HB* and give a cheesy little smile. If she gives a nice smile back any opener will do becuase she is most likely intersted. Saves a lot of time with approaching those whom are not as interested. Of course real pickup is getting the uninterested turned around and saying, "I could get a date with HB10, watch". That is still a bit beyond my current powers though.
Great book and highly recommended.