Ok, so I'm not 100% sure if this is actually a secret or not, but in the Midwest it isn't that known. Now this isn't a pickup line, or a routine, but rather where I've had the best success (at minimum a number every time I go).
The secret: Gay Clubs. I know what you're thinking "HAHA. This guy cannot be serious!" But hear me out. Straight girls go to gay clubs so that they are not hit on... The thing is, is that once she is at the club SHE WANTS TO BE PICKED UP. Now, gay guys have very attractive friends, so this generally cuts down on the amount of non-attractive girls there. Not to mention there isn't alot of competition around.
The negatives: the gay clubs that I've been to are dance clubs, so you'll have to learn to dance. But if you aren't being serious and look like you're having a good time, this is always good for a laugh and they are generally cool with teaching you how to dance. Also, you will most likely be hit on by a few guys. Take this as a compliment as you are (obviously) attractive.
Once there, almost all of the same guidelines apply. And if you're ever in the Dayton, OH area send me a message. Have fun and let me know how it goes.