I don't claim to be saying anything that hasn't been said before, but nevertheless, a couple tips on opening. And here I'm just talking about bars, which is pretty much my favorite place to meet girls.
I'm naturally more of a laid back guy who doesn't find it easy to open. Many of you are too. All you have to do is realize it and adjust. You have to find whatever it is that breaks down your barrier. For me, it just have to get some social interaction in and get the juices flowing. How do I do that? It's silly, but I high five people. Anyone. I do it until my social brain is awake and ready to interact with people. Once that's done, my secret is simple. I talk to everyone. Male, female, mixed sets, everyone. And I don't approach it as an "opener," I just approach it as meeting people.
In fact one thing I'll often say, to guys or girls, is simply, "I haven't met you yet, have I? Hi." It's that simple. I do that until I'm talking to people and I know a lot of people.
I can't tell you how many times that has led me to meet a guy who knows a girl who, voila, ended up being interested in me.
The other tip is also simple but always bears repeating. It doesn't matter what you say. Just say something. Sometimes the dumbest stuff I've said has worked. Because the words don't matter. Just pick something and go. Direct, situational, whatever. Just get the interaction started. You do it enough, you'll succeed on some of them without even doing anything "right." Because the only truly "right" thing to do is to just do something.